OUR TEAM
OUR TEAM
A leading manufacturer and supplier of
human untagged ubiquitin-proteasome complexes
About us
The Proteasome Center specializes in isolating untagged 19S, 20S, 26S, and COP9 signalosome protein complexes of the ubiquitin-proteasome system from human red blood cells, as well as untagged 20S immunoproteasome from the human spleen.
We deliver exclusively high-quality proteasome proteins to leading pharmaceutical companies and research laboratories all around the world (USA, Europe, UK, China).
The ubiquitin-proteasome system
is a key cellular mechanism for regulating protein levels and quality. In this system, proteins destined for degradation are tagged with ubiquitin that signals the cell to transport these tagged proteins to the proteasome. The proteasome is a large complex that breaks down these proteins into smaller fragments, which the cell can then reuse.
This system is crucial for controlling various cellular processes, including cell cycle regulation, DNA repair, and response to stress.
The proteasome
is a large protein complex responsible for degrading and recycling unwanted or damaged proteins in cells. It consists of a cylindrical 20S core particle, where protein breakdown occurs, and one or two 19S regulatory particles that recognize and process proteins tagged with ubiquitin.
This complex plays a key role in maintaining cellular health by controlling protein quality and regulating various cellular processes.
Our Products
Our customers
Companies
Research universities
Company leaders
Dr. amnon golan
Founder and CEo
Dr. Amnon Golan earned his PhD from The Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, where he was mentored by Prof. Avram Hershko, a Nobel laureate, followed by a postdoctoral fellowship at Yale University.
Throughout his career, Dr. Golan has specialized in studying human homologous proteins and complexes, with a particular focus on the ubiquitin-proteasome system. He holds extensive hands-on expertise in isolating proteasome protein complexes using advanced fractionation techniques.
Dr. oleg chmelnik
CTO, Senior scientist
Dr. Oleg Chmelnik holds a PhD in Biotechnology and Food Engineering from the Technion - Israel Institute of Technology. His academic career focused on engineering and studying the structure-function relationships in glycosynthases, followed by joining The Proteasome Center, where he gained expertise in isolating proteasome protein complexes.
He has extensive practical expertise in the expression, purification, characterization, and engineering of proteins, as well as directed evolution of enzymes, enzyme kinetics, and various molecular biology techniques.
